Immortalization of Human Keratinocytes Using the Catalytic Subunit of Telomerase
نویسندگان
چکیده
منابع مشابه
Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.
Normal human somatic cells have a finite life span and undergo replicative senescence after a limited number of cell divisions. Erosion of telomeric DNA has emerged as a key factor in senescence, which is antagonized during cell immortalization and transformation. To clarify the involvement of telomerase in the immortalization of keratinocytes, catalytic subunit of telomerase (hTERT) expression...
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ژورنال
عنوان ژورنال: Doklady Biochemistry and Biophysics
سال: 2021
ISSN: 1607-6729,1608-3091
DOI: 10.1134/s1607672921010014